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Saikia B, Tang J, Robinson S, Nichani S, Lawman KB, Katre M, Bandi S. Neonates With SARS-CoV-2 Infection and Pulmonary Disease Safely Treated With Remdesivir. Pediatr Infect Dis J. 2021 May 1;40(5):e194-e196. doi: 10.1097/INF.0000000000003081. PMID: 33847299.

We describe 2 expremature infants presenting with SARS-CoV-2-related pulmonary disease in their second and fifth week of life needing support with mechanical ventilation. Both infants’ initial presentation was with repeated apneas. These cases highlight that SARS-CoV-2 infection could present with apneas and has the potential to progress to more severe pulmonary disease in this high-risk age group of patients. Both patients were treated with remdesivir (RDV). We provide the data of 2 high-risk neonates successfully treated with RDV without observation of any described side effects. A recognition that these high-risk neonates could deteriorate and early multidisciplinary team discussion is the mainstay to the compassionate access to RDV. Our experience led us to develop a guideline on the use of RDV below 12 years of age, with particular focus on infants and young children.

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