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Sugimura T, Seo T, Terasaki N, Ozaki Y, Rikitake N, Okabe R, Matsushita M. Efficacy and safety of breast milk eye drops in infants with eye discharge. Acta Paediatr. 2020 Oct 23. doi: 10.1111/apa.15628. Epub ahead of print. PMID: 33098117.

Aim: Breast milk(BM) contains various protective components, such as immunoglobulins, lactoferrin, lysozyme, oligosaccharides, and immune cell subsets. We evaluated the effectiveness of BM eye drops in infants with eye discharge in a randomised controlled study.

Methods: Subjects were breastfed infants aged ≤ 180 days, with eye discharge. We randomly assigned patients to receive eye drops of BM or sodium azulene sulfonate hydrate 0.02% ophthalmic solution (OS). The patients received drop of BM or OS for 7 days. Improvement score of eye discharge in the groups was compared using a non-inferiority test.

Results: The number of patients improved eye discharge was 119/155 (76.8%) and 119/157 (75.8%) in BM and OS groups, respectively. There were no significant differences between groups. The improvement score in eye discharge was 1.76±0.91 in the BM group and 1.71±0.96 in the OS group. The BM group was considered non-inferior to the OS group.

Conclusions: This study demonstrated that BM is no less effective than OS in infants with eye discharge aged ≤ 6 months. The results suggested that the use of breast milk as eye drops could be considered as a first-line treatment for infants aged ≤ 6 months with eye discharge.

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