Aim: Breast milk（BM） contains various protective components, such as immunoglobulins, lactoferrin, lysozyme, oligosaccharides, and immune cell subsets. We evaluated the effectiveness of BM eye drops in infants with eye discharge in a randomised controlled study.
Methods: Subjects were breastfed infants aged ≤ 180 days, with eye discharge. We randomly assigned patients to receive eye drops of BM or sodium azulene sulfonate hydrate 0.02% ophthalmic solution (OS). The patients received drop of BM or OS for 7 days. Improvement score of eye discharge in the groups was compared using a non-inferiority test.
Results: The number of patients improved eye discharge was 119/155 (76.8%) and 119/157 (75.8%) in BM and OS groups, respectively. There were no significant differences between groups. The improvement score in eye discharge was 1.76±0.91 in the BM group and 1.71±0.96 in the OS group. The BM group was considered non-inferior to the OS group.
Conclusions: This study demonstrated that BM is no less effective than OS in infants with eye discharge aged ≤ 6 months. The results suggested that the use of breast milk as eye drops could be considered as a first-line treatment for infants aged ≤ 6 months with eye discharge.