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Seidler AL, Gyte GML, Rabe H, Díaz-Rossello JL, Duley L, Aziz K, Testoni Costa-Nobre D, Davis PG, Schmölzer GM, Ovelman C, Askie LM, Soll R; INTERNATIONAL LIAISON COMMITTEE ON RESUSCITATION NEONATAL LIFE SUPPORT TASK FORCE. Umbilical Cord Management for Newborns <34 Weeks' Gestation: A Meta-analysis. Pediatrics. 2021 Mar;147(3):e20200576. doi: 10.1542/peds.2020-0576. PMID: 33632931; PMCID: PMC7924139.

Context: The International Liaison Committee on Resuscitation prioritized scientific review of umbilical cord management strategies at preterm birth.

Objective: To determine the effects of umbilical cord management strategies (including timing of cord clamping and cord milking) in preterm infants <34 weeks’ gestation.

Data sources: Cochrane Central Register of Controlled Trials, Medline, PubMed, Embase, CINAHL, and trial registries were searched through July 2019 for randomized controlled trials assessing timing of cord clamping and/or cord milking.

Study selection: Two authors independently assessed trial eligibility, extracted data, appraised risk of bias, and assessed evidence certainty (GRADE).

Data extraction: We identified 42 randomized controlled trials (including 5772 infants) investigating 4 different comparisons of cord management interventions.

Results: Compared to early cord clamping, delayed cord clamping (DCC) and intact-cord milking (ICM) may slightly improve survival; however, both are compatible with no effect (DCC: risk ratio: 1.02, 95% confidence interval: 1.00 to 1.04, n = 2988 infants, moderate certainty evidence; ICM: risk ratio: 1.02, 95% confidence interval: 0.98 to 1.06, n = 945 infants, moderate certainty evidence). DCC and ICM both probably improve hematologic measures but may not affect major neonatal morbidities.

Limitations: For many of the included comparisons and outcomes, certainty of evidence was low. Our subgroup analyses were limited by few researchers reporting subgroup data.

Conclusions: DCC appears to be associated with some benefit for infants born <34 weeks. Cord milking needs further evidence to determine potential benefits or harms. The ideal cord management strategy for preterm infants is still unknown, but early clamping may be harmful.

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