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Kaluarachchi DC, Nicksic VM, Allen DB, Eickhoff JC, Dawe SJ, Baker MW. Thyroid-stimulating hormone reference ranges for moderate-to-late preterm infants. J Perinatol. 2020 Dec 5. doi: 10.1038/s41372-020-00895-6. Epub ahead of print. PMID: 33279944.

Background: Identifying congenital hypothyroidism through newborn screening (NBS) is higher among moderate-to-late preterm (MLPT) infants. Currently, the same thyroid-stimulating hormone (TSH) cutoffs are used for term and preterm infants. TSH reference ranges for MLPT infants are not currently available.

Objective: To determine TSH reference ranges for MLPT infants.

Methods: We analyzed 10,987 TSH levels on NBS samples performed on 8499 MLPT infants born between 32 and 36 weeks gestation.

Results: TSH median, 5th, 25th, 75th, 95th, and 99th percentiles were defined from day 1 until day 14 of life. TSH levels gradually decreased after birth and reached a plateau around day 6.

Conclusion: Using a state-wide cohort, we constructed TSH reference charts from day 1 until day 14 for MLPT infants. Relationship between age-adjusted TSH percentiles and long-term neurodevelopmental outcomes should be determined in future studies to define optimal TSH cutoffs for MLPT infants.

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