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Dani C, Pratesi S, Luzzati M, Petrolini C, Montano S, Remaschi G, Coviello C. Cerebral and splanchnic oxygenation during automated control of inspired oxygen (FiO2 ) in preterm infants. Pediatr Pulmonol. 2021 Mar 26. doi: 10.1002/ppul.25379. Epub ahead of print. PMID: 33773084.

Objectives: Our aim in this study was to assess the effect of the Predictive Intelligent Control of Oxygenation (PRICO®) system on cerebral (rSO2 C) and splanchnic (rSO2 S) oxygenation in a cohort of preterm infants with frequent desaturations.

Methods: Twenty infants with gestational age <32 weeks (n = 20) were assigned in random sequence to 12 h of automated or manual adjustment of FiO2 . Over this period, they were studied continuously by near-infrared spectroscopy (NIRS).

Results: We found that rSO2 C [68.0% (60.5%-74.7%) vs. 68.5% (62%-72%); p = .824] and rSO2 S [27.0% (17.3%-45.7%) vs. 27.0% (15%-53%); p = .878] were similar during automatic and manual control of FiO2 . Time spent with SpO2 90%-95% was higher during the automatic than manual control of FiO2 , while time spent with SpO2 <80% or >95% was lower.

Conclusions: Automated control of FiO2 with PRICO® system did not improve brain and splanchnic oxygenation in comparison with manual control in a cohort of preterm infants, but it significantly decreased SpO2 fluctuations and limited the duration of both hypoxemia and hyperoxemia.

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