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Aghajani MH, Moradi O, Amini H, Tehrani HA, Pourheidar E, Rabiei MM, Sistanizad M. Decreased In-Hospital Mortality Associated with Aspirin Administration in Hospitalized Patients Due to Severe COVID-19. J Med Virol. 2021 Apr 29. doi: 10.1002/jmv.27053. Epub ahead of print. PMID: 33913549.

Introduction: Hypercoagulability and thrombosis caused by COVID-19 is related to the higher mortality rate. Because of limited data on antiplatelet effect, we aimed to evaluate the impact of aspirin add-on therapy on the outcome of the patients hospitalized due to severe COVID-19.

Materials and methods: In this cohort study, patients with a confirmed diagnosis of severe COVID-19 admitted to Imam Hossein Medical Center, Tehran, Iran from March 2019 to July 2020 were included. Demographics and related clinical data during their hospitalization were recorded. The mortality rate of the patients was considered as the primary outcome and its association with aspirin use was assessed.

Results: Nine hundred and ninety-one patients were included that 336 patients of them (34%) received aspirin during their hospitalization and 655 ones (66%) did not. Comorbidities were more prevalent in the patients who were receiving aspirin. Results from the multivariate COX proportional model demonstrated a significant independent association between aspirin use and reduction in risk of in-hospital mortality (0.746[0.560-0.994], P=0.046).

Conclusions: Aspirin use in hospitalized patients with COVID-19 is associated with a significant decrease in mortality rate. Further prospective randomized controlled trials are needed to assess the efficacy and adverse effects of aspirin administration in this population. This article is protected by copyright. All rights reserved.

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