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Wungu CDK, Khaerunnisa S, Putri EAC, Hidayati HB, Qurnianingsih E, Lukitasari L, Humairah I, Soetjipto. Meta-analysis of cardiac markers for predictive factors on severity and mortality of COVID-19. Int J Infect Dis. 2021 Mar 9:S1201-9712(21)00225-3. doi: 10.1016/j.ijid.2021.03.008. Epub ahead of print. PMID: 33711519; PMCID: PMC7942156.

Objective: Previous observational studies suggested that increased cardiac markers are commonly found in COVID-19. This study aimed to determine the relationship between several cardiac markers and the severity/mortality of COVID-19 patients.

Methods: We analysed several cardiac markers in this meta-analysis. RevMan 5.4 was used to provide pooled estimates for standardized mean difference (SMD) with 95% confidence intervals.

Results: Twenty nine clinical studies were included in this meta-analysis. This study found significantly higher CKMB (0.64, 95% CI = 0.19-1.09,), PCT (0.47, 95% CI = 0.26-0.68), NT-proBNP (1.90, 95% CI = 1.63-2.17), BNP (1.86, 95% CI = 1.63-2.09), and D-dimer (1.30, 95% CI = 0.91-1.69) in severe compared to non-severe COVID-19. This study also found significantly higher CKMB (3.84, 95% CI = 0.62-7.05), PCT (1.49, 95% CI = 0.86-2.13), NT-proBNP (4.66, 95% CI = 2.42-6.91,), BNP (1.96, 95% CI = 0.78-3.14), troponin (1.64 (95% CI = 0.83-2.45), and D-dimer (2.72, 95% CI = 2.14-3.29) in death cases compared to survived cases with COVID-19.

Conclusions: In conclusion, high CKMB, PCT, NT-proBNP, BNP, and D-dimer could be predictive markers for the severity of COVID-19, while high CKMB, PCT, NT-proBNP, BNP, troponin, and D-dimer could be predictive markers for the survival of COVID-19 patients.

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