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O’Boyle DS, Dunn WB, O’Neill D, Kirwan JA, Broadhurst DI, Hallberg B, Boylan GB, Murray DM. Improvement in the Prediction of Neonatal Hypoxicischemic Encephalopathy with the Integration of Umbilical Cord Metabolites and Current Clinical Makers. J Pediatr. 2020 Oct 8:S0022-3476(20)31257-9. doi: 10.1016/j.jpeds.2020.09.065. Epub ahead of print. PMID: 33039387.

Objective: To validate our previously identified candidate metabolites, and to assess the ability of these metabolites to predict hypoxic-ischemic encephalopathy (HIE) both individually and combined with clinical data. Study design:

APPROFONDISCI
26 Ottobre 2020

Antoine J, Inglis GDT, Way M, O’Rourke P, Davies MW. Bacterial colonisation of the endotracheal tube in ventilated very preterm neonates: A retrospective cohort study [published online ahead of print, 2020 Aug 17]. J Paediatr Child Health. 2020;10.1111/jpc.15046. doi:10.1111/jpc.15046

Aim: To determine the rate, type and timing of bacterial endotracheal tube (ETT) colonisation in neonates born <32 weeks gestational age (GA); and if bacterial colonisation is associated with chronic

APPROFONDISCI
26 Ottobre 2020

Rozé JC, Ancel PY, Marchand-Martin L, Rousseau C, Montassier E, Monot C, Le Roux K, Butin M, Resche-Rigon M, Aires J, Neu J, Lepage P, Butel MJ; EPIFLORE Study Group. Assessment of Neonatal Intensive Care Unit Practices and Preterm Newborn Gut Microbiota and 2-Year Neurodevelopmental Outcomes. JAMA Netw Open. 2020 Sep 1;3(9):e2018119. doi: 10.1001/jamanetworkopen.2020.18119. PMID: 32965499; PMCID: PMC7512059.

Importance: In very preterm newborns, gut microbiota is highly variable with major dysbiosis. Its association with short-term health is widely studied, but the association with long-term outcomes remains unknown. Objective: To investigate

APPROFONDISCI
26 Ottobre 2020

El-Khuffash A, Bussmann N, Breatnach CR, Smith A, Tully E, Griffin J, McCallion N, Corcoran JD, Fernandez E, Looi C, Cleary B, Franklin O, McNamara PJ. A Pilot Randomized Controlled Trial of Early Targeted Patent Ductus Arteriosus Treatment Using a Risk Based Severity Score (The PDA RCT). J Pediatr. 2020 Oct 15:S0022-3476(20)31291-9. doi: 10.1016/j.jpeds.2020.10.024. Epub ahead of print. PMID: 33069668.

Objectives: To evaluate the feasibility of recruiting preterm infants to a randomized controlled trial of patent ductus arteriosus (PDA) treatment based on a PDA severity score (PDAsc) and to characterize

APPROFONDISCI
26 Ottobre 2020

Annink KV, de Vries LS, Groenendaal F, Vijlbrief DC, Weeke LC, Roehr CC, Lequin M, Reiss I, Govaert P, Benders MJNL, Dudink J. The development and validation of a cerebral ultrasound scoring system for infants with hypoxic-ischaemic encephalopathy. Pediatr Res. 2020 Mar;87(Suppl 1):59-66.

Background: Hypoxic-ischaemic encephalopathy (HIE) is an important cause of morbidity and mortality in neonates. When the gold standard MRI is not feasible, cerebral ultrasound (CUS) might offer an alternative. In

APPROFONDISCI
26 Ottobre 2020

Vesoulis ZA, Whitehead HV, Liao SM, Mathur AM. The hidden consequence of intraventricular hemorrhage: persistent cerebral desaturation after IVH in preterm infants. Pediatr Res. 2020 Oct 10. doi: 10.1038/s41390-020-01189-5. Epub ahead of print. PMID: 33038871.

Background: Previous studies describe a short-term decrease in cerebral oxygen saturation (StO2) after intraventricular hemorrhage (IVH) in premature infants; little is known about long-term implications. Methods: Infants born <30 weeks gestational age

APPROFONDISCI
26 Ottobre 2020

WHO Rapid Evidence Appraisal for COVID-19 Therapies (REACT) Working Group, Sterne JAC, Murthy S, Diaz JV, Slutsky AS, Villar J, Angus DC, Annane D, Azevedo LCP, Berwanger O, Cavalcanti AB, Dequin PF, Du B, Emberson J, Fisher D, Giraudeau B, Gordon AC, Granholm A, Green C, Haynes R, Heming N, Higgins JPT, Horby P, Jüni P, Landray MJ, Le Gouge A, Leclerc M, Lim WS, Machado FR, McArthur C, Meziani F, Møller MH, Perner A, Petersen MW, Savovic J, Tomazini B, Veiga VC, Webb S, Marshall JC. Association Between Administration of Systemic Corticosteroids and Mortality Among Critically Ill Patients With COVID-19: A Meta-analysis. JAMA. 2020 Sep 2;324(13):1–13. doi: 10.1001/jama.2020.17023. Epub ahead of print. PMID: 32876694; PMCID: PMC7489434.

Importance: Effective therapies for patients with coronavirus disease 2019 (COVID-19) are needed, and clinical trial data have demonstrated that low-dose dexamethasone reduced mortality in hospitalized patients with COVID-19 who required

APPROFONDISCI
25 Ottobre 2020

Walsh KA, Spillane S, Comber L, Cardwell K, Harrington P, Connell J, Teljeur C, Broderick N, de Gascun CF, Smith SM, Ryan M, O’Neill M. The duration of infectiousness of individuals infected with SARS-CoV-2. J Infect. 2020 Oct 10:S0163-4453(20)30651-4. doi: 10.1016/j.jinf.2020.10.009. Epub ahead of print. PMID: 33049331; PMCID: PMC7547320.

Objectives: To summarise the evidence on the duration of infectiousness of individuals in whom SARS-CoV-2 ribonucleic acid is detected. Methods: A rapid review was undertaken in PubMed, Europe PubMed Central and EMBASE

APPROFONDISCI
25 Ottobre 2020

Meyerowitz EA, Richterman A, Gandhi RT, Sax PE. Transmission of SARS-CoV-2: A Review of Viral, Host, and Environmental Factors. Ann Intern Med. 2020 Sep 17:M20-5008. doi: 10.7326/M20-5008. Epub ahead of print. PMID: 32941052; PMCID: PMC7505025.

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the etiologic agent of coronavirus disease 2019 (COVID-19), has spread globally in a few short months. Substantial evidence now supports preliminary conclusions about

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25 Ottobre 2020
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