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Month: Maggio 2021

Ambalavanan N, Shankaran S, Laptook AR, Carper BA, Das A, Carlo WA, Cotten CM, Duncan AF, Higgins RD; EUNICE KENNEDY SHRIVER NICHD NEONATAL RESEARCH NETWORK. Early Determination of Prognosis in Neonatal Moderate or Severe Hypoxic-Ischemic Encephalopathy. Pediatrics. 2021 May 13:e2020048678. doi: 10.1542/peds.2020-048678. Epub ahead of print. PMID: 33986149.

Background and objectives: Early determination of prognosis is important in neonates with hypoxic-ischemic encephalopathy (HIE). Our objective was to test scoring systems developed earlier (original scoring system) and develop new prognostic

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He Z, Zhu S, Zhou K, Jin Y, He L, Xu W, Lao C, Liu G, Han S. Sildenafil for pulmonary hypertension in neonates: An updated systematic review and meta-analysis. Pediatr Pulmonol. 2021 May 13. doi: 10.1002/ppul.25444. Epub ahead of print. PMID: 33983650.

Objectives: To provide an updated review and meta-analysis on the efficacy and safety of sildenafil for treating persistent pulmonary hypertension in neonates (PPHN). Methods: PubMed/Medline, SCOPUS, Cochrane Central Register of Controlled Trials,

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Samiee-Zafarghandy S, van Donge T, Fusch G, Pfister M, Jacob G, Atkinson A, Rieder MJ, Smit C, Van Den Anker J. Novel strategy to personalise use of ibuprofen for closure of patent ductus arteriosus in preterm neonates. Arch Dis Child. 2021 May 11:archdischild-2020-321381. doi: 10.1136/archdischild-2020-321381. Epub ahead of print. PMID: 33975823.

Objective: Exploration of a novel therapeutic drug monitoring (TDM) strategy to personalise use of ibuprofen for closure of patent ductus arteriosus (PDA) in preterm neonates. Design: Prospective, single-centre, open-label, pharmacokinetics study in

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Lund LC, Hallas J, Nielsen H, Koch A, Mogensen SH, Brun NC, Christiansen CF, Thomsen RW, Pottegård A. Post-acute effects of SARS-CoV-2 infection in individuals not requiring hospital admission: a Danish population-based cohort study. Lancet Infect Dis. 2021 May 10:S1473-3099(21)00211-5. doi: 10.1016/S1473-3099(21)00211-5. Epub ahead of print. PMID: 33984263; PMCID: PMC8110209.

Background: Individuals admitted to hospital for COVID-19 might have persisting symptoms (so-called long COVID) and delayed complications after discharge. However, little is known regarding the risk for those not admitted to

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Lopez Bernal J, Andrews N, Gower C, Robertson C, Stowe J, Tessier E, Simmons R, Cottrell S, Roberts R, O’Doherty M, Brown K, Cameron C, Stockton D, McMenamin J, Ramsay M. Effectiveness of the Pfizer-BioNTech and Oxford-AstraZeneca vaccines on covid-19 related symptoms, hospital admissions, and mortality in older adults in England: test negative case-control study. BMJ. 2021 May 13;373:n1088. doi: 10.1136/bmj.n1088. PMID: 33985964; PMCID: PMC8116636.

Objective: To estimate the real world effectiveness of the Pfizer-BioNTech BNT162b2 and Oxford-AstraZeneca ChAdOx1-S vaccines against confirmed covid-19 symptoms (including the UK variant of concern B.1.1.7), admissions to hospital, and deaths.

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Keshavarz P, Yazdanpanah F, Azhdari S, Kavandi H, Nikeghbal P, Bazyar A, Rafiee F, Nejati SF, Sadabad FE, Rezaei N. Coronavirus Disease 2019 (COVID-19): A Systematic Review of 133 Children Presented with Kawasaki-like Multisystem Inflammatory Syndrome. J Med Virol. 2021 May 10. doi: 10.1002/jmv.27067. Epub ahead of print. PMID: 33969513.

Background: Kawasaki-like disease (KLD) and multisystem inflammatory syndrome in children (MIS-C) are considered as challenges for pediatric patients under the age of 18 infected with coronavirus disease 2019 (COVID-19). Methods: A systematic

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Puneet G, Surender K, Sudhan SS. SARS-CoV-2 prevalence, maternal and perinatal outcomes among pregnant women admitted for delivery: Experience from Covid-19 dedicated maternity hospital in Jammu, Jammu and Kashmir (India). J Med Virol. 2021 May 11. doi: 10.1002/jmv.27074. Epub ahead of print. PMID: 33974301.Background: Impact of SARS-CoV-2 infection in pregnant women and their neonates is exotic area of research now a days. Till date, there is limited knowledge about SARS-CoV-2 prevalence, maternal and perinatal outcomes of pregnant women at term in middle and low income countries. Methods: In present retro-prospective study, medical records of pregnant women admitted for delivery were reviewed from the largest Covid-19 dedicated Shri Maharaja Gulab Singh (SMGS) maternity hospital. SARS-CoV-2 screening was carried out for all pregnant women admitted for delivery using RT-PCR. All neonates born from SARS-CoV-2 positive mothers were isolated and tested for SARS-CoV-2 infection. Results: Most of pregnant women (90.6%) were asymptomatic at the time of admission with low prevalence (3.4%) of SARS-CoV-2. Higher rate of asymptomatic prevalence (86.1%) was found among SARS-CoV-2 positive pregnant women.On the basis of the RT-PCR result (negative vs. positive), statistically significant differences were found for maternal characteristics such as Mean gestational age (37.5 ± 2.2 vs. 36.6 ± 3.3), Medical comorbidity (2.9% vs. 7.4%), and Maternal outcomes such as the C-section rate (29.8% vs. 58.3%), Preterm delivery (14.6% vs. 28.3), and neonatal outcomes such as Mean Birth weight (2840±450 vs. 2600± 600), Low Apgar score (2.7% vs 6.48%), Fetal distress (10.9% vs 22.2 %) among SARS-CoV-2 negative cases and SARS-CoV-2 positives respectively. No neonate from SARS-CoV-2 positive pregnant women was found to be positive for SARS-CoV-2 infection. Conclusion: SARS-CoV-2 infection has deleterious effects on maternal characteristics, obstetric complications, maternal and perinatal outcomes along in pregnant women admitted for delivery.

Background: Impact of SARS-CoV-2 infection in pregnant women and their neonates is exotic area of research now a days. Till date, there is limited knowledge about SARS-CoV-2 prevalence, maternal and perinatal

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Ko JY, DeSisto CL, Simeone RM, Ellington S, Galang RR, Oduyebo T, Gilboa SM, Lavery AM, Gundlapalli AV, Shapiro-Mendoza CK. Adverse pregnancy outcomes, maternal complications, and severe illness among U.S. delivery hospitalizations with and without a COVID-19 diagnosis. Clin Infect Dis. 2021 May 12:ciab344. doi: 10.1093/cid/ciab344. Epub ahead of print. PMID: 33977298.

Background: Evidence on risk for adverse outcomes from COVID-19 among pregnant women is still emerging. We examined the association between COVID-19 at delivery and adverse pregnancy outcomes, maternal complications, and severe

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