Mese: Settembre 2020

Capetti AF, Borgonovo F, Morena V, et al. Short-term inhibition of SARS-CoV-2 by hydrogen peroxide in persistent nasopharyngeal carriers [published online ahead of print, 2020 Sep 3]. J Med Virol. 2020;10.1002/jmv.26485. doi:10.1002/jmv.26485

Asymptomatic and convalescent COVID-19 subjects may carry SARS-CoV-2 for months in their upper respiratory ways. Desiring to permanently clean the mucosal surfaces we investigated chemical agents fit to rapidly degrade the virus. Among these, hydrogen peroxide, initially tested by two of us for tolerability, showed both good performance and acceptable side effects (burning sensation for 15 – 20 seconds). We contacted circles of family physicians and the ATS Milano (Territorial Assistance and Prevention Service) and we tested this procedure on eight persistent carriers of SARS-CoV-2, performing swabs before the procedure and after it until reappearance of the virus or until 14 days (the incubation period), keeping the surfaces clean with hypertonic solution. Our patients had a median time from exposure or symptom onset of 111 days and three had relapsed after being declared ‘cured’ (two consecutive negative swabs after quarantine). One patient had a baseline negative swab and was excluded, two successfully ended the 14 days’ course, four suppressed viral elimination for 72 hours and one for 48 hours, all rebounding to weak positive (cycle thresholds above 24). Although temporarily effective, such measure may have some place in the control of viral shedding, in order to protect the most fragile subjects. This article is protected by copyright. All rights reserved.

Arafkas M, Khosrawipour T, Kocbach P, et al. Current meta-analysis does not support the possibility of COVID-19 reinfections [published online ahead of print, 2020 Sep 8]. J Med Virol. 2020;10.1002/jmv.26496. doi:10.1002/jmv.26496

Background: COVID-19 reinfections could be a major aggravating factor in this current pandemic, as this would further complicate potential vaccine development and help to maintain worldwide virus pockets. To investigate this critical question, we conducted a clinical meta-analysis including all available currently reported cases of potential COVID-19 reinfections.

Methods: We searched for all peer-reviewed articles in the search engine of the National Center for Biotechnology Information. While there are over 30.000 publications on COVID-19, only about 15 specifically target the subject of COVID-19 reinfections. Available patient data in these reports was analyzed for age, gender, time of reported relapse after initial infection and persistent COVID-19 positive PCR results.

Results: Following the first episode of infection, cases of clinical relapse are reported at 34 (mean) ± 10,5 days after full recovery. Patients with clinical relapse have persisting positive COVID-19 PCR testing results until 39 ± 9 days following initial positive testing. For patients without clinical relapse, positive testing was reported up to 54 ± 24 days. There were no reports of any clinical reinfections after a 70-day period following initial infection.

Conclusions: Reports of COVID-19 reinfections all appear within a vulnerable timeframe, where affected patients are still tested positive for COVID-19 via PCR. According to our data, it is most likely that all reported cases of COVID-19 reinfections are in fact protracted initial infections. To diagnose a true COVID-19 reinfection, positive COVID-19 testing combined with recurrent clinical symptoms occurring outside of this timeframe is required. This article is protected by copyright.

CALO DELLE NASCITE: NEL 2021 INCIDERA’ ANCHE IL COVID

“Ogni anno perdiamo dalle 17 alle 19 mila nascite ed è ovvio che il Covid, avendo creato incertezza e preoccupazione, aumenta la probabilità di scendere sotto le 400 mila nascite nel 2021. Il Covid inciderà in maniera esponenziale su questo calo, perché si va a inserire una variabile negativa su un terreno che già è grandemente in difficoltà da tempo”.
Il Presidente della SIN, Prof. Fabio Mosca, in un’intervista all’agenzia Dire, sul calo della natalità, un problema rilevante nel nostro Paese.

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La SIN è una società, non a fini di lucro, che persegue e allarga gli scopi ed obiettivi del Gruppo di Lavoro di Neonatologia della Società Italiana di Pediatria (SIP).